Identificacion Principal del registro INGC-EBK-000551

Control Number Identifier AR-LpUFI

LAST MODIFICATION DATE 20160908092821

CONTROL FIELD cr nn 008mamaa

CONTROL FIELD 140520s2014 gw | s |||| 0|eng d

a International Standard Book Number 9783319070827

a Standard number or code 10.1007/978-3-319-07082-7

a Personal name Jens, Marvin.

a Title Dissecting Regulatory Interactions of RNA and Protein

h Medium [libro electrónico] : ;

b Remainder of title Combining Computation and High-throughput Experiments in Systems Biology /

c Statement of responsibility, etc by Marvin Jens.

a Place of publication, distribution, etc Cham :

b Name of publisher, distributor, etc Springer International Publishing :

b Name of publisher, distributor, etc Imprint: Springer,

c Date of publication, distribution, etc 2014.

a Extent xviii, 99 p. :

b Other physical details il.

a Series statement Springer Theses, Recognizing Outstanding Ph.D. Research,

x International Standard Serial Number 2190-5053

a Formatted contents note Introduction -- Computational analysis of PAR-CLIP data -- Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR -- Binding site occupancy with competition interactions in equilibrium -- Circular RNAs are a large class of animal RNAs with regulatory potency -- Discussion -- Methods.

a Summary, etc The work described in this book is an excellent example of interdisciplinary research in systems biology. It shows how concepts and approaches from the field of physics can be efficiently used to answer biological questions, and reports on a novel methodology involving creative computer-based analyses of high-throughput biological data. Many of the findings described in the book, which are the result of collaborations between the author (a theoretical scientist) and experimental biologists, and between different laboratories, have been published in high-quality peer-reviewed journals such as Molecular Cell and Nature. However, while those publications address different aspects of post-transcriptional gene regulation, this book provides readers with a complete, coherent and logical view of the research project as a whole. The introduction presents post-transcriptional gene regulation from a distinct angle, highlighting aspects of information theory and evolution, and laying the groundwork for the questions addressed in the subsequent chapters, which concern the regulation of the transcriptome as the primary functional carrier of active genetic information.

a Topical term or geographic name as entry element Engineering.

a Topical term or geographic name as entry element Gene expression.

a Topical term or geographic name as entry element Biochemistry.

a Topical term or geographic name as entry element Systems biology.

a Topical term or geographic name as entry element Biological systems.

a Topical term or geographic name as entry element Computational intelligence.

a Topical term or geographic name as entry element Biological Networks

u Uniform Resource Identifier (R) http://dx.doi.org/10.1007/978-3-319-07082-7

c item type EBK

a descripción COM